Human Plasma Kallikrein-Kinin System: Physiological and Biochemical Parameters
نویسندگان
چکیده
منابع مشابه
Human urinary kallikrein - biochemical and physiological aspects.
The h i s t o r y of k a l l i k r e i n begins w i t h the d i s c o v e r y of u r i n a r y k a l l i k r e i n more than f i f t y years ago. The r e n a l o r i g i n of u r i n a r y k a l l i k r e i n , though not f i n a l l y proved, i s l a r g e l y accepted. A p o s s i b l e r o l e of k a l l i k r e i n i n the r e g u l a t i o n of kidney f u n c t i o n and blood pressure has...
متن کاملThe plasma kallikrein-kinin system counterbalances the renin-angiotensin system.
(KKS), first recognized over 40 years ago, was originally believed to contribute to physiologic hemostasis. At the time, factor XII (Hageman factor, FXII) and the related proteins prekallikrein (PK) and high molecular–weight kininogen (HK) were known to be essential for efficient surface-activated blood coagulation, as measured in the activated partial thromboplastin time (APTT) test. Indeed, i...
متن کاملLack of Plasma Kallikrein-Kinin System Cascade in Teleosts
The kallikrein-kinin system (KKS) consists of two major cascades in mammals: "plasma KKS" consisting of high molecular-weight (HMW) kininogen (KNG), plasma kallikrein (KLKB1), and bradykinin (BK); and "tissue KKS" consisting of low molecular-weight (LMW) KNG, tissue kallikreins (KLKs), and [Lys(0)]-BK. Some components of the KKS have been identified in the fishes, but systematic analyses have n...
متن کاملKallikrein-kinin system in neovascularization.
Kinin System in Neovascularization − Kallikrein Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2009 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/ATVBAHA.109.184549 2009;29:617-619 Arterioscler Thromb Vasc Biol. http://atvb.a...
متن کاملThe renal kallikrein-kinin system.
THE KIDNEY contains several hormonal systems—kallikrein-kinin, renin-angiotensin, prostaglandin—which serve as renal self-regulatory mechanisms and may have extrarenal effects as well. Although the functions of the kallikrein-kinin system are incompletely defined, there is evidence that it may regulate renal blood flow, modulate tubular salt and water transport, and participate in the pathogene...
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ژورنال
عنوان ژورنال: Cardiovascular & Hematological Agents in Medicinal Chemistry
سال: 2009
ISSN: 1871-5257
DOI: 10.2174/187152509789105444